Kurzfassung

The current gold-standard methods for analyzing the formation of new bone, histology and micro-Computed Tomography, are invasive and/or destructive, harming research subjects and rendering analyses by other means difficult or impossible. DCE-MRI has been demonstrated to be accurate in assessing tissue perfusion, particularly in oncology. Its advantages are the high sensitivity of contrast agents and the absence of ionizing radiation, which facilitate longitudinal monitoring of angiogenesis in...The current gold-standard methods for analyzing the formation of new bone, histology and micro-Computed Tomography, are invasive and/or destructive, harming research subjects and rendering analyses by other means difficult or impossible. DCE-MRI has been demonstrated to be accurate in assessing tissue perfusion, particularly in oncology. Its advantages are the high sensitivity of contrast agents and the absence of ionizing radiation, which facilitate longitudinal monitoring of angiogenesis in animals, as well as in patients. Therefore, DCE- MRI may facilitate assessing the development of the vascular network and the efficacy of osteoplastic materials in subjects submitted to bone regenerative procedures. The aim of the present study is to assess the accuracy and reproducibility of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in monitoring neovascularization after guided bone regeneration and to evaluate whether the initial area under the contrast concentration versus time curve at 60 seconds after contrast agent (IAUC60), a DCE-MRI pharmacokinetic parameter of blood perfusion, is a reliable surrogate of the efficacy of osteoplastic materials.» weiterlesen» einklappen