Kurzfassung

Unilateral traumatic brain injuries (TBI) lead to cell death and functional loss in the area of the impact. Interestingly, neurons in the homotopic area of the primarily undamaged, contralateral hemisphere cortex were recently shown to express a neuronal hyperactivity after 24 hours following the injury in mice. The cellular mechanisms underlying these functional changes are not understood. These most likely adaptive changes can contribute to functional reorganization after the TBI, however...Unilateral traumatic brain injuries (TBI) lead to cell death and functional loss in the area of the impact. Interestingly, neurons in the homotopic area of the primarily undamaged, contralateral hemisphere cortex were recently shown to express a neuronal hyperactivity after 24 hours following the injury in mice. The cellular mechanisms underlying these functional changes are not understood. These most likely adaptive changes can contribute to functional reorganization after the TBI, however they could also be maladaptive. Thus, a better understanding of these processes could provide useful information for future therapeutical strategies in humans. Since fibers of the corpus callosum provide an interhemispheric transfer of information, the aim of the present project was to examine a potential contribution of callosal fibers on neuronal activity in the primarily undamaged contralateral hemisphere after a traumatic brain injury.» weiterlesen» einklappen