BAG3-mediated selective macroautophagy and its modulation (TP A03) - SFB 1177/1 "Molecular and Functional Characterization of Selective Autophagy"
Laufzeit: 01.01.2016 - 31.12.2019
Kurzfassung
Aggregated proteins as associated with neurodegenerative disorders have been shown to be primary targets of selective autophagy involving the co-chaperone BAG3. In this project this process will be investigated focusing on substrate recognition and requirements, kinetics of aggresome targeting, and its regulation by endo- and exogenous factors. The role of post-translational modifications for BAG3 function will be analyzed as well. To get a detailed insight into the dynamics of the autophagy...Aggregated proteins as associated with neurodegenerative disorders have been shown to be primary targets of selective autophagy involving the co-chaperone BAG3. In this project this process will be investigated focusing on substrate recognition and requirements, kinetics of aggresome targeting, and its regulation by endo- and exogenous factors. The role of post-translational modifications for BAG3 function will be analyzed as well. To get a detailed insight into the dynamics of the autophagy network, the BAG3 interactome will be characterized under different cellular conditions and the crosstalk with other autophagy routes (e.g. mitophagy) will be assessed.
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Veröffentlichungen
- Spang, Natalie; Feldmann, Anne; Huesmann, Heike et al.
- RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
- Gamerdinger, M; Kaya, AM; Wolfrum, U et al.
- BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins
- Gamerdinger, M; Carra, S; Behl, C
- Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins
- Gamerdinger, M; Hajieva, P; Kaya, AM et al.
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
