Kurzfassung

Bioadhesives are functional biopolymers with potential applications in wound healing and tissue engineering. Pectin, a plant-based heteropolysaccharide, has recently shown therapeutic potential as a mucoadhesive in the gut. Since mucoadhesion is a process likely involving the interpenetration of the pectin polymer with mucin chains, we hypothesized that pectin may also be effective at targeting the glycocalyx of the visceral mesothelium. In this project, the interaction of various pectin...Bioadhesives are functional biopolymers with potential applications in wound healing and tissue engineering. Pectin, a plant-based heteropolysaccharide, has recently shown therapeutic potential as a mucoadhesive in the gut. Since mucoadhesion is a process likely involving the interpenetration of the pectin polymer with mucin chains, we hypothesized that pectin may also be effective at targeting the glycocalyx of the visceral mesothelium. In this project, the interaction of various pectin formulations with the mesothelium of the lung, liver, bowel, and heart is studied. Tensile strength, peel strength, and shear resistance of the bioadhesive-mesothelial interaction will be determined by displacement measurements.» weiterlesen» einklappen