Kurzfassung

Our investigations of recent years resulted in a novel understanding of the processes of bone mineralization, such as the initial formation of bioseeds from amorphous calcium carbonate (ACC), the carbonate-phosphate exchange, resulting in the formation of amorphous calcium phosphate (ACP) and its maturation to hydroxyapatite. Furthermore, we have shown for the first time that certain inorganic polymers, inorganic polyphosphate (polyP) and biosilica are morphogenetically active: they induce...Our investigations of recent years resulted in a novel understanding of the processes of bone mineralization, such as the initial formation of bioseeds from amorphous calcium carbonate (ACC), the carbonate-phosphate exchange, resulting in the formation of amorphous calcium phosphate (ACP) and its maturation to hydroxyapatite. Furthermore, we have shown for the first time that certain inorganic polymers, inorganic polyphosphate (polyP) and biosilica are morphogenetically active: they induce the differentiation of mesenchymal precursor cells to mineralizing osteoblasts, as well as the sequential expression of the enzymes involved in the mineralization process. The aim of the project is to develop a novel printable and implantable hydrogel scaffold material that contains morphogenetically active core-shell microparticles consisting of either a biosilica core and a polyP shell or a calcium-polyP core and a silica shell. These amorphous calcium-polyP or amorphous biosilica-containing microparticles or hydrogel scaffold materials containing these particles are expected to be morphogenetically active and promote the regeneration of bone tissue. In contrast to inert scaffold materials, these materials should not require the addition of cytokines/growth factors. They should be able to induce the enzymes involved in bone formation and growth factors. The 3D printable material to be developed is planned to be used for the fabrication of personalized implants
 
 » weiterlesen» einklappen