Which genes enable the morphological adaptation of the receptor cells during light and dark.
Laufzeit: 01.01.2011 - 31.12.2015
Kurzfassung
In their service in the adaptation to the daily alternation of light and dark, the photoreceptor cells undergo neogenesis of the outer segments, the reconstruction of the synapse, and the necessary intracellular transport processes with a daily rhythm. In this project the daily adaptation of the outer segments and the synapse are being investigated at the gene level. For this purpose a microarray gene was identified, which in its expression shows a daily rhythm and at the same time is...In their service in the adaptation to the daily alternation of light and dark, the photoreceptor cells undergo neogenesis of the outer segments, the reconstruction of the synapse, and the necessary intracellular transport processes with a daily rhythm. In this project the daily adaptation of the outer segments and the synapse are being investigated at the gene level. For this purpose a microarray gene was identified, which in its expression shows a daily rhythm and at the same time is relevant for the protein configuration of the outer segments and the synapse or for the molecular transport within the photoreceptor cell.
The research project is a co-operation between the Wolfrum (FB10) and Spessert groups (FB04) groups and is being supported by the NMFZ (Science and Medical Research Centre).» weiterlesen» einklappen
Veröffentlichungen
- Kunst, Stefanie; Wolloscheck, Tanja; Hoelter, Philip et al.
- Transcriptional analysis of rat photoreceptor cells reveals daily regulation of genes important for visual signaling and light damage susceptibility
- Hoelter, Philip; Kunst, Stefanie; Wolloscheck, Tanja et al.
- The Retinal Clock Drives the Expression of Kcnv2, a Channel Essential for Visual Function and Cone Survival