Kurzfassung

As seen in the currently available literature, some controversy exists concerning the cellular effects of infrared-A irradiation (IR-A) on human skin. While a whole range of effects (both positive and negative) have been described in numerous in vivo and in vitro models, many of the studies are flawed by the use of inappropriate experimental set-ups and erroneous interpretation of results. There is therefore a definite need for further studies examining the cellular effects of IR-A under...As seen in the currently available literature, some controversy exists concerning the cellular effects of infrared-A irradiation (IR-A) on human skin. While a whole range of effects (both positive and negative) have been described in numerous in vivo and in vitro models, many of the studies are flawed by the use of inappropriate experimental set-ups and erroneous interpretation of results. There is therefore a definite need for further studies examining the cellular effects of IR-A under carefully designed and controlled experimental conditions. A customized inverse microscope has been constructed for this project which allows not only the direct application of IRA to cells (e.g., fibroblasts) in culture but also the simultaneous observation of cellular changes. Additional use of molecular probes will allow a more detailed assessment of cellular alterations (e.g., production of reactive oxygen species, apoptosis, etc.). » weiterlesen» einklappen