Kurzfassung

Dental materials, especially the ones that are to be employed during an endodontic treatment, should fulfill the corresponding requirements. These type of materials are placed in the root canal; thus, they are relatively often in direct contact with the periapical tissues. At our laboratories we constantly investigate, with multiple research methodologies, the biocompatibility degree of these type of materials. The in vitro research methods which allow to obtain a first sight evaluation of...Dental materials, especially the ones that are to be employed during an endodontic treatment, should fulfill the corresponding requirements. These type of materials are placed in the root canal; thus, they are relatively often in direct contact with the periapical tissues. At our laboratories we constantly investigate, with multiple research methodologies, the biocompatibility degree of these type of materials. The in vitro research methods which allow to obtain a first sight evaluation of these materials play a decisive role in their clinical employment. With these methodologies we are able to determine the metabolism (proliferation, apoptosis, cytokine release among others) caused by these materials on different cell lines. The metabolism processes are supported through visualization by means of a fluorescence microscope.
A special research interest subject of our investigations are the different formulations of  zinc-oxide eugenol, calcium phosphate and epoxy resin based root canal sealers and their effect on the cell metabolism.
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