Kurzfassung

The orthodontic dreatment of adult patients is getting more and more popular. Patients with osteoporosis and intake of bisphosphonates are a new challenge for orthodontic treatment. For the orthodontic tooth movement bone-turnover of the alveolar bone is necessary and induced by the applied forces on the teeth. The periodontium and the alveolar bone reacts with bone apposition and resorption. Bisphosphonates do also influence these mechanism of burn turn-over. Periostin is an important...The orthodontic dreatment of adult patients is getting more and more popular. Patients with osteoporosis and intake of bisphosphonates are a new challenge for orthodontic treatment. For the orthodontic tooth movement bone-turnover of the alveolar bone is necessary and induced by the applied forces on the teeth. The periodontium and the alveolar bone reacts with bone apposition and resorption. Bisphosphonates do also influence these mechanism of burn turn-over. Periostin is an important adhesionsprotein supporting the cell-matrix-contacts. It plays an important role in the regulation of the remodelling of the periodontium. Aim of this study is to analyze the effects of mechanical loading and bisphosphonates on the periostin synthesis of HPdLF.
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