Kurzfassung

Bisphosphonate associated necrosis of the jaw (BP-ONJ) is one of the main side effect of the bisphosphonate therapy in patients with metastatic cancer or benign bone diseases like osteoporosis or Paget diseases. These patients have an increase risk for development of avascular necrosis after dental implantation or surgical procedure. Specially Nitrogen-containing bisphosphonates (N-BPs) decrease the synthesis of mevalonat pathway metabolites like Geranylgeraniol (GGOH) by specific inhibition...Bisphosphonate associated necrosis of the jaw (BP-ONJ) is one of the main side effect of the bisphosphonate therapy in patients with metastatic cancer or benign bone diseases like osteoporosis or Paget diseases. These patients have an increase risk for development of avascular necrosis after dental implantation or surgical procedure. Specially Nitrogen-containing bisphosphonates (N-BPs) decrease the synthesis of mevalonat pathway metabolites like Geranylgeraniol (GGOH) by specific inhibition of pyrophosphate synthase (FPPS). Until now there is now established causal therapeutic options for these patients. Other and we could demonstrate that GGOH can rescue the negative effect of bisphosphonates (BP). Therefore local treatment of GGOH could lead to a new therapeutic strategy for BP-ONJ.» weiterlesen» einklappen