Kurzfassung

 Intrinsic childhood brain tumours (CBTs) are the most common type of solid tumour in children and leading cause of death among all pediatric cancers. There are no effective treatments for recurrent malignant CBTs. The introduction of genome-wide RNA sequencing (RNAseq), has allowed an unprecedented depth of information about gene expression patterns to study mechanisms of therapeutic resistance. However transcriptome data on recurrent pediatric brain tumours are scarce. The study aims... Intrinsic childhood brain tumours (CBTs) are the most common type of solid tumour in children and leading cause of death among all pediatric cancers. There are no effective treatments for recurrent malignant CBTs. The introduction of genome-wide RNA sequencing (RNAseq), has allowed an unprecedented depth of information about gene expression patterns to study mechanisms of therapeutic resistance. However transcriptome data on recurrent pediatric brain tumours are scarce. The study aims at exploring the potential of massively parallel RNA sequencing in identifying molecular traits of post-treatment recurrence and predicting treatment regimens best suited to gene expression profiles in individual patients. Study objectives 1) Identify and functional validate targetable genes and signaling pathways associated with post-treatment recurrence; 2) Evaluate the impact of intratumoural heterogeneity on the results of transcriptome analyses;3) Enable individualized therapy (IT) for children with brain cancer at the University Medical Center Mainz.» weiterlesen» einklappen