Kurzfassung

Penile carcinoma is a rare but aggressive cancer with a high incidence in developing countries. Advanced penile cancer is most commonly treated with a combination therapy including cisplatin (CDDP) and 5-fluorouracil (5-FU). However, therapy resistance limits the anti-tumoral effect. Alterations in the PI3K/Akt/mTOR pathway might be involved. Thus, it is our objective to evaluate the relevance of this pathway in penile cancer in vitro and in vivo.