Kurzfassung

Vitamin D spielt eine wichtige Rolle im Knochenstoffwechsel und für die Muskelfunktion. Verschiedenste neue Studien zeigten eine alarmierend hohe Verbreitung erniedrigter Vitamin D Spiegel in der Allgemeinbevölckerung. Das Ziel der vorliegenden Studie war es, das Ausmaß bestehender Vitamin D-Defizienz unter orthopädischen Patienten aufzuzeigen.

Background:
Vitamin D is essential for optimal bone health and muscle function. An alarmingly high rate of vitamin-D
deficiency in the general population...Vitamin D spielt eine wichtige Rolle im Knochenstoffwechsel und für die Muskelfunktion. Verschiedenste neue Studien zeigten eine alarmierend hohe Verbreitung erniedrigter Vitamin D Spiegel in der Allgemeinbevölckerung. Das Ziel der vorliegenden Studie war es, das Ausmaß bestehender Vitamin D-Defizienz unter orthopädischen Patienten aufzuzeigen.

Background:
Vitamin D is essential for optimal bone health and muscle function. An alarmingly high rate of vitamin-D
deficiency in the general population has been reported recently. The purpose of the present study was to characterize the extent of low serum levels of vitamin D among orthopaedic surgery patients.

Methods:
We used gas chromatography with mass spectrometry coupling to measure the 25OH vitamin D level of 1119 patients scheduled to undergo orthopaedic surgery (65% women) who were consecutively admitted to the clinic of orthopaedic surgery University Hospital, Mainz, Germany, from January 1st to December 31st 2011. Their mean and median age was 58 years.

Results: Overall, 43% of all patients had insufficient serum vitamin-D levels, and, of these, 40% had deficient levels. Among the orthopaedic services, the highest rates of low serum vitamin-D levels were seen in the trauma and sports services, in which the rates of abnormal (insufficient and deficient) vitamin-D levels were 66% and 52%, respectively. The lowest rate of abnormal vitamin-D levels was seen in the metabolic bone disease service. Patients between the ages of fifty-one and seventy years were 35% less likely to have low vitamin-D levels than patients between the ages of eighteen and fifty years (p = 0.018). The prevalence of low vitamin-D levels was significantly higher in men (p = 0.006). Individuals with darker skin tones (blacks and Hispanics) were 5.5 times more likely to have low vitamin-D levels when compared with those with lighter skin tones (whites and Asians) (p < 0.001).

Conclusions:
The prevalence of low serum levels of vitamin D among patients undergoing orthopaedic surgery is very common. Given the importance of vitamin D in musculoskeletal health, such low levels may negatively impact patient outcomes.
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