Kurzfassung

Multiple sclerosis (MS) is a prototypic chronic inflammatory central nervous system (CNS) disorder, where inflammation, neurodegeneration and repair occur concurrently in the central nervous system. As the disease typically begins in young adulthood, it results in a tremendous socio-economic burden. Although therapeutic options for early and active forms of the disease have improved in recent years, there are many unresolved questions related to our lack of understanding of factors...Multiple sclerosis (MS) is a prototypic chronic inflammatory central nervous system (CNS) disorder, where inflammation, neurodegeneration and repair occur concurrently in the central nervous system. As the disease typically begins in young adulthood, it results in a tremendous socio-economic burden. Although therapeutic options for early and active forms of the disease have improved in recent years, there are many unresolved questions related to our lack of understanding of factors determining disease susceptibility, initiation, perpetuation, phenotype variation and disability progression.

Spokesperson: Heinz Wiendl (Münster)
Co-Spokesperson: Frauke Zipp (Dept. of Neurology)

Projects with a co-PI from Mainz:
• A03: G-protein-coupled receptor signaling in immune cells and endothelial cells: implications for neuroinflammation (Wettschureck/ Waisman)
• A07: A novel IL-6 signalling modality in the direct interaction of immune cells (Waisman/Korn)
• A08: Impact of dietary factors on the gut-CNS-axis – implications for CNS autoimmunity (Klotz/Schuppan)
• B04: T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells (Bopp/Zipp)
• B05: Identifying distinct functional and structural connectivity patterns of network compensation and repair in early autoimmune neuroinflammation (Groppa/Zipp/Meuth)
• B07: Oligodendrocyte progenitor cells in de- and remyelination: release of differentiation brakes in mouse and human cells (Trotter/Kulmann)
• B09: Mechanisms underlying immune-mediated neuronal damage: neuronal hyperexcitability as starting point for neurodegeneration in Multiple Sclerosis (Stroh/Zipp)
• B11: A role for meningeal lymphatic vessels in the regulation of CNS inflammation (Kipnis)
• B12: Role of two pore domain potassium channel signalling in CNS immunity and inflammatory neuronal injury (Bittner)
• Z02: Clinical translational Unit (Wiendl/Gold/Hemmer/Hohlfeld/Kuhlmann/Zipp)» weiterlesen» einklappen