Kurzfassung

This joint, interdisciplinary project between the groups of Marianne Müller (Translational Psychiatry, University Medical Center) and Vijay Tiwari (Epigenetic Regulation of Development and Disease, IMB Mainz/JGU Mainz) follows an innovative approach with the overarching aim to identify transcriptome and epigenetic signatures of early antidepressant treatment response specifically in the hippocampal dentate gyrus, one of the relevant target regions of antidepressant action. Ultimately, as a...This joint, interdisciplinary project between the groups of Marianne Müller (Translational Psychiatry, University Medical Center) and Vijay Tiwari (Epigenetic Regulation of Development and Disease, IMB Mainz/JGU Mainz) follows an innovative approach with the overarching aim to identify transcriptome and epigenetic signatures of early antidepressant treatment response specifically in the hippocampal dentate gyrus, one of the relevant target regions of antidepressant action. Ultimately, as a proof of translatability of our data to human disease conditions, we will investigate whether candidate genes or candidate epigenetic modifications identified in the mouse might be involved in conferring risk for depression.» weiterlesen» einklappen