Kurzfassung

In order to investigate if an anti-lL-36R antibody can be used for the treatment of IL-17A-driven of IL- 17 A-driven psoriatic syndromes, we want to perform the following experiments
1. Anti-lL-36R antibody treatment of mice with an established IMQ-induced psoriasis-like skin inflammation.
2. Anti-lL-36R antibody treatment of Kl4-IL17Aind Nfkbizt1/+ mice before disease onset (prophylactic protocol).
3.Anti-lL-36R antibody treatment of K14-IL17Aind Nfkbiz111+ mice after the development...In order to investigate if an anti-lL-36R antibody can be used for the treatment of IL-17A-driven of IL- 17 A-driven psoriatic syndromes, we want to perform the following experiments
1. Anti-lL-36R antibody treatment of mice with an established IMQ-induced psoriasis-like skin inflammation.
2. Anti-lL-36R antibody treatment of Kl4-IL17Aind Nfkbizt1/+ mice before disease onset (prophylactic protocol).
3.Anti-lL-36R antibody treatment of K14-IL17Aind Nfkbiz111+ mice after the development of psoriatic lesions (therapeutic protocol).» weiterlesen» einklappen