Kurzfassung

The aim of the project is to (i) correlate the chromatin landscape of recurrent MLL and translocation partner genes breakpoints with topoisomerase-II occupancy in human hematopoietic stem cells (ii) assess the effect of specific chromatin/histone modifiers in the formation of these translocations (iii) screen for epigenetic inhibitors that reduce MLL translocations and (iv) establish protocols for early translocation detection using HT-FISH in primary CD34+ bone marrow cells of patients...The aim of the project is to (i) correlate the chromatin landscape of recurrent MLL and translocation partner genes breakpoints with topoisomerase-II occupancy in human hematopoietic stem cells (ii) assess the effect of specific chromatin/histone modifiers in the formation of these translocations (iii) screen for epigenetic inhibitors that reduce MLL translocations and (iv) establish protocols for early translocation detection using HT-FISH in primary CD34+ bone marrow cells of patients previously treated with etoposide.» weiterlesen» einklappen