Kurzfassung

Type-2 cytokines like interleukin-4, interleukin-5 and interleukin-13 play an essential role in the pathogenesis of eosinophilic allergic bronchial asthma. However, the precise function of each cytokine alone or their synergistically interplay on eosinophil migration and activation and other hallmarks of the airway disease is not fully understood. Aim of this project is to analyze the impact of lung applied type-2 cytokines on the migration, proliferation and activation of eosinophils in the...Type-2 cytokines like interleukin-4, interleukin-5 and interleukin-13 play an essential role in the pathogenesis of eosinophilic allergic bronchial asthma. However, the precise function of each cytokine alone or their synergistically interplay on eosinophil migration and activation and other hallmarks of the airway disease is not fully understood. Aim of this project is to analyze the impact of lung applied type-2 cytokines on the migration, proliferation and activation of eosinophils in the bone marrow, blood, lung and bronchoalveolar lavage (BAL). Additionally, the influence of the cytokines on further hallmarks of an allergic airway response, like airway hyper responsiveness and goblet cell metaplasia will be analyzed.
Identical amounts of cytokines were installed intranasally, alone side by side, or, to analyze possible synergistic effects, in combination. Furthermore, by administration of blocking antibodies the precise role of each cytokine will be analyzed in the synergistic setup.


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