Kurzfassung

In an effort to investigate the impact of stroma-mediated drug resistance, we established a co-culture system using distinct stromal feeder layers and human AML cell lines/ primary human AML blasts. Co-culture of AML cells on stromal feeder layers inhibited cytarabine or midostaurin-induced apoptotic cell death, as revealed by cell cycle analysis and Annexin V staining. In this project, we are planning to apply this well-defined co-culture system to analyse the effects of several...In an effort to investigate the impact of stroma-mediated drug resistance, we established a co-culture system using distinct stromal feeder layers and human AML cell lines/ primary human AML blasts. Co-culture of AML cells on stromal feeder layers inhibited cytarabine or midostaurin-induced apoptotic cell death, as revealed by cell cycle analysis and Annexin V staining. In this project, we are planning to apply this well-defined co-culture system to analyse the effects of several chemotherapeutics and dasatinib upon treatment with an anti-CXCR4 antibody.
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