Kurzfassung

Arterial hypertension induced by angiotensin II, the main blood pressure hormone, is characterized by vascular inflammation, mainly driven by inflammatory monocytes and a proinflammatory cytokine and chemokine microenvironment in the vascular wall. The presence of lysozyme (LysM)+ inflammatory cells containing intact angiotensin II receptor signaling and a functional gp91phox  containing NADPH oxidase appears to be indispensable for the deleterious effects of angiotensin II. However,...Arterial hypertension induced by angiotensin II, the main blood pressure hormone, is characterized by vascular inflammation, mainly driven by inflammatory monocytes and a proinflammatory cytokine and chemokine microenvironment in the vascular wall. The presence of lysozyme (LysM)+ inflammatory cells containing intact angiotensin II receptor signaling and a functional gp91phox  containing NADPH oxidase appears to be indispensable for the deleterious effects of angiotensin II. However, mechanisms of recruitment and expansion of these cells in hypertensive vascular damage are incompletely understood.  With this proposal we will address the research question, how inflammatory myeloid cells infiltrate the vascular wall in response to angiotensin II in vivo.» weiterlesen» einklappen