Kurzfassung

The blood coagulation factor XII-driven contact system is a procoagulant plasma
protease cascade. In animal models, factor XII has been shown to be essential for arterial
thrombus formation; however, deficiency of the protease does not impair hemostasis. Inorganic
polymers, polyphosphates, initiate the contact system on activated platelets and defective polyphosphate-
driven factor XII activation interferes with thombus stability. We will analyze arterial
and venous thrombosis in factor XII...The blood coagulation factor XII-driven contact system is a procoagulant plasma
protease cascade. In animal models, factor XII has been shown to be essential for arterial
thrombus formation; however, deficiency of the protease does not impair hemostasis. Inorganic
polymers, polyphosphates, initiate the contact system on activated platelets and defective polyphosphate-
driven factor XII activation interferes with thombus stability. We will analyze arterial
and venous thrombosis in factor XII deficient humans and the importance of polyphosphates for
prostate cancer-driven fibrin formation. This project will establish the role of the contact system
for thromboembolic disease and factor XII as an anti-thrombotic drug target. The main objectives
are: 1) to analyze incidence and severity of arterial and venous thrombotic disease in humans
with severe FXII deficiency and 2) to characterize the function of the coagulation factor
XII-driven contact system for prostate cancer-associated thrombosis.» weiterlesen» einklappen