Kurzfassung

Epstein-Barr-induced gene three and asthma: EBI-3 is expressed by tissue macrophages and dendritic cells (DC) which play an important functional role in asthma. Furthermore, EBI-3 deficiency, in contrast to IL-27 inactivation, was described by us to be associated with a diminished production of Th2 cytokines. In addition, we discovered that allergen challenge led to the development of a population of EBI-3-/- myeloid DC (mDC) which released increased amounts of IL-10 and IL-12, thus...Epstein-Barr-induced gene three and asthma: EBI-3 is expressed by tissue macrophages and dendritic cells (DC) which play an important functional role in asthma. Furthermore, EBI-3 deficiency, in contrast to IL-27 inactivation, was described by us to be associated with a diminished production of Th2 cytokines. In addition, we discovered that allergen challenge led to the development of a population of EBI-3-/- myeloid DC (mDC) which released increased amounts of IL-10 and IL-12, thus inhibiting AHR in the absence of EBI-3.
Antigen presentation plays an important role in lung metastasis, although the immunological mechanisms are not completely understood.
EBI-3 and lung melanoma: Epstein-Barr virus-induced gene 3(EBI-3) is expressed by antigen presenting cells following activation. Here we demonstrate that mice lacking EBI-3 survive B16-F10-induced metastasis significantly longer than wild-type mice by inducing a CLT response in the lung.
IL-2 signaling in lung tumour:T regulatory cells are known to suppress the T cell mediated immune-responses at the site of the tumor development thus contributing to the development of this devastating disease.We thus asked the question how do T regulatory cells contribute to the suppression of the T effector cells seen intratumorally in the lung ?
In this study we used a murine model of broncho-adenocarcinoma to better understand the mechanism by which T regulatory cells (CD4+CD25+-Foxp3 +) inhibit the CD4+ T cells mediated immune responses.
NFATc2 and lung tumour: Lung cancer, including bronchoalveolar- adenocarcinoma is the major cause of death in the USA and Europe. The transcription factors nuclear factor of activated T cells (NFATs) are critical in regulating early gene transcription in response to T cell receptor mediated signals in lymphocytes. In the present study, we show, in a murine bronchoalveolar adenocarcinoma, that mice lacking NFATc2 developed increased lung metastasis characterized by decreased necrosis in tumour cells as compared to those developed in the lung of the wild type littermates.
» weiterlesen» einklappen