Kurzfassung

Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by activated CD4 [+] memory T cells shown to increase the growth rate of human cervical tumors transplanted into athymic nude mice. However, IL-17 increased the generation of specific cytolytic T lymphocytes (CTLs) directed against the immunodominant antigens.
Given the importance of the newly discovered T helper 17 cells and their pathogenetic role in autoimmune discorders as well as in tumour we aimed, in this project, at the...Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by activated CD4 [+] memory T cells shown to increase the growth rate of human cervical tumors transplanted into athymic nude mice. However, IL-17 increased the generation of specific cytolytic T lymphocytes (CTLs) directed against the immunodominant antigens.
Given the importance of the newly discovered T helper 17 cells and their pathogenetic role in autoimmune discorders as well as in tumour we aimed, in this project, at the investigation of the role of IL-17 in lung tumour both in human and in a murine model of broncho-adeno-carcinoma.
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