Kurzfassung

The research group of Ari Waisman in Mainz is using conditional gene targeting in three main approaches:
Tissue-specific ablation of genes involved in brain inflammation using brain-specific Cre mice. Mice that express Cre in oligodendrocytes are used to delete Fas, CYLD or gp130. e.g. to study the role of Fas in EAE (Fas-mediated death of oligodendrocytes in brain inflammation).
The role of different APC in brain inflammation. A new mouse model was generated that allow the expression of a...The research group of Ari Waisman in Mainz is using conditional gene targeting in three main approaches:
Tissue-specific ablation of genes involved in brain inflammation using brain-specific Cre mice. Mice that express Cre in oligodendrocytes are used to delete Fas, CYLD or gp130. e.g. to study the role of Fas in EAE (Fas-mediated death of oligodendrocytes in brain inflammation).
The role of different APC in brain inflammation. A new mouse model was generated that allow the expression of a MOG-derived peptide by MHC class II of specific APC. Using this mouse model a role for B cells in peripheral tolerance induction in vivo was recently shown
The role of secreted antibodies in immune responses with emphasis on autoimmune responses and function of IgG1 as B cell receptor (BCR). In this project two knock in mice are used: in the first strain an IgM BCR leads to the development of IgM+ B cells that do not secrete antibodies and in the second strain an IgG1 BCR derives the development only of IgG1+ B cells.
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