Kurzfassung

The introduction of an efficient 44Ti/44Sc nuclide generator promotes Sc-44 as an interesting isotope for clinical and preclinical PET studies. Sc-44 decays at a rate of 94.3 % by positron emission with a half-life of approximately 4 h.  In comparison to Ga-68, Sc-44 exhibits a significantly lower positron energy (Sc-44: = 0.63 MeV, Ga-68: = 0.83 MeV), resulting in a lower positron range and a better intrinsic resolution. However, during the stabilization process of Sc-44, additional...The introduction of an efficient 44Ti/44Sc nuclide generator promotes Sc-44 as an interesting isotope for clinical and preclinical PET studies. Sc-44 decays at a rate of 94.3 % by positron emission with a half-life of approximately 4 h.  In comparison to Ga-68, Sc-44 exhibits a significantly lower positron energy (Sc-44: = 0.63 MeV, Ga-68: = 0.83 MeV), resulting in a lower positron range and a better intrinsic resolution. However, during the stabilization process of Sc-44, additional gamma-quanta [1157 keV] are emitted at a high rate [> 99 %], influencing the image quality.  The project aims at  the qualitative and quantitative performance evaluation of Sc-44 compared to Ga-68 using two different preclinical PET systems.
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