Kurzfassung

Purpose: to estimate mean pulmonary arterial pressure (mPAP) in patients with CTEPH by analysing flow parameters of the pulmonary trunc derived from high temporal resolution phase-contrast MR-Imaging (PC-MRI).
Materials and Methods: We prospectively examined 8 CTEPH patients with high temporal resolution PC-MRI at 1.5 T (Magnetom Sonata , Siemens Medical Solutions) with simultaneous invasive pressure recordings in the pulmonary trunc. Imaging parameters for PC-MRI were as follows: TR = 10...Purpose: to estimate mean pulmonary arterial pressure (mPAP) in patients with CTEPH by analysing flow parameters of the pulmonary trunc derived from high temporal resolution phase-contrast MR-Imaging (PC-MRI).
Materials and Methods: We prospectively examined 8 CTEPH patients with high temporal resolution PC-MRI at 1.5 T (Magnetom Sonata ®, Siemens Medical Solutions) with simultaneous invasive pressure recordings in the pulmonary trunc. Imaging parameters for PC-MRI were as follows: TR = 10 msec, TE = 2.5 msec, Flip = 15 °, velocity encoding = 100 cm/sec, bandwidth = 977 Hz/pixel, 3 averages. The parameters absolute and relative acceleration time ATa [mesc] and ATr [%], peak of mean velocities MRV [cm/sec], and distensibility DIS [%] were evaluated according to Proc. Intl Soc Mag Reson Med 2003; 11: 407, and were used to compute mPAP with the following regression equation: mPAP–PC-MRI [mmHg] = 88.9- 0.29 * ATa – 1.1 * ATr – 0.38 * MFV – 0.16 * DIS.
Results: MPAP-MRI correlated very well with simultaneous invasive pressure recordings in all patients (linear coefficient of determination R2 = 0.979, p < 0.001, median difference +2.0 mm Hg, range –1.9 - + 4.7 mm Hg).
Conclusion: Non-invasive mPAP-estimations are possible in CTEPH-patients by means of high temporal resolution PC-MRI and correlate well with simultaneous invasively measured values.
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