Kurzfassung

The cannabinoid receptor system is composed of its type 1 (CB1) and type 2 (CB2) receptors, its endogenous ligands and degrading enzymes. In the brain, CB1 receptors are found among others in regions involved in motor control, memory function and regulation of the autonomic nervous system. The phytocannabinoid Δ9-tetrahydrocannabinol (THC) is the psychoactive component of the plant Cannabis sativa and acts as an agonist at cannabinoid type 1 and type 2 receptors. It has been shown that THC...The cannabinoid receptor system is composed of its type 1 (CB1) and type 2 (CB2) receptors, its endogenous ligands and degrading enzymes. In the brain, CB1 receptors are found among others in regions involved in motor control, memory function and regulation of the autonomic nervous system. The phytocannabinoid Δ9-tetrahydrocannabinol (THC) is the psychoactive component of the plant Cannabis sativa and acts as an agonist at cannabinoid type 1 and type 2 receptors. It has been shown that THC affects a variety of physiological and psychological processes, such as impairment of motor coordination and short-time memory function and increase in appetite. The cerebral metabolic rate of glucose (CMRglc) in the brain as a surrogate parameter for neuronal activity can be assessed, using dynamic acquisition of [18F]FDG accumulation by Positron-Emission-Tomography (PET) together with pharmacokinetic modelling analyses. The goal of this study was to assess the effect of THC on the cerebral metabolic rate of glucose in the rat brain.» weiterlesen» einklappen