Kurzfassung

Recently, B lymphocytes have attracted much attention in the cardiovascular research field. A network-driven integrative analyses of data from genome-wide association studies and whole blood gene expression profiles from Framingham Heart Study participants indicate that dysregulation of B lymphocytes may represent a key driver of coronary heart disease (CHD). In accordance with this concept, we have found compelling evidence for protective effects of B lymphocytes in maintaining vascular...Recently, B lymphocytes have attracted much attention in the cardiovascular research field. A network-driven integrative analyses of data from genome-wide association studies and whole blood gene expression profiles from Framingham Heart Study participants indicate that dysregulation of B lymphocytes may represent a key driver of coronary heart disease (CHD). In accordance with this concept, we have found compelling evidence for protective effects of B lymphocytes in maintaining vascular function and hemostasis. In the present research proposal, the molecular mechanisms underlying the role of B cells in maintaining vascular function and hemostasis as well as the molecular mechanisms of B cell dysregulation in obesity will be studied.» weiterlesen» einklappen