Kurzfassung

It is well known that among the potential routes for mucosal immunization, there are many advantages regarding the oral route, such as: (a) no need for medically trained personnel; (b) potential for self administration; (c) no risk of injury and cross infection; (d) painless, high acceptability by the public; (e) large potential for formulation (tablets, syrups, inclusion in drinks or foods); (f) environment-friendly with fewer issues related to disposal, decontamination and incineration of...It is well known that among the potential routes for mucosal immunization, there are many advantages regarding the oral route, such as: (a) no need for medically trained personnel; (b) potential for self administration; (c) no risk of injury and cross infection; (d) painless, high acceptability by the public; (e) large potential for formulation (tablets, syrups, inclusion in drinks or foods); (f) environment-friendly with fewer issues related to disposal, decontamination and incineration of waste products. Thus, non-invasive oral vaccination is very attractive for mass-vaccination programs, particularly in the developing world. However, despite the development of the Sabin oral polio vaccine in the early 1960s, few mucosal vaccines have been developed, and some are no longer used or have been withdrawn due to harmful side effects. While the oral route would be a most convenient and thus preferred mucosal vaccination modality, the normal immune response to antigens encountered in the GIT leans toward systemic tolerance, which is meant to protect from commensal organisms. Furthermore, the low gastric pH and hydrolytic enzymes of the digestive system cause ingested proteins and carbohydrates to be degraded and their conformational epitopes destroyed. Thus, for effective oral immunization, the antigens must be protected from the harsh environment of the GIT. This project is based on the use of the Giardia most abundant surface proteins for protection from degradation of vaccinal antigens included onto or into VLPs for the generation of novel oral vaccines.
We anticipate with this project that it will allow us to develop efficient oral vaccines important for infections.» weiterlesen» einklappen