Kurzfassung

The main objective of the project is to obtain via a modelling and simulation approach a better understanding of the structure and dynamics of metabolic pathways of gene regulatory networks involved in the morphogenesis of animals and plants. We will concentrate on the development of two kinds of sponges and on the organogenesis of carpel and anthers of a flowering plant. We will tackle the complexity involved in these processes by using concepts and tools arising from complex systems...The main objective of the project is to obtain via a modelling and simulation approach a better understanding of the structure and dynamics of metabolic pathways of gene regulatory networks involved in the morphogenesis of animals and plants. We will concentrate on the development of two kinds of sponges and on the organogenesis of carpel and anthers of a flowering plant. We will tackle the complexity involved in these processes by using concepts and tools arising from complex systems science. On the one side morphogenesis of sponges and organogenesis in flowering plants share many common concerns and approaches which justify the feasibility of tackling them within a common complex systems framework. On the other side they consider distinguished features and methods of analysis that will guarantee a minimal genericity in the tools designed for the modelling process. The following problems will be addressed: provide a general model allowing the description of the underlying complex systems at different hierarchical levels in the same formalism; provide tools to extract concrete models description from experimental data; provide a way to conduct in-silico experiments. These tools will be applied on real data in order to significantly progress on the initial biological problems and will also be used to develop a model-guided data collection process. Moreover, the simulation tools will be modular enough to be customised or extended in the future for modelling complex systems arising from other fields. Our global goals can be summarised by three measurable and verifiable objectives: to build patio-temporal atlases of gene expression for flowering plants (for carpel and anther) and one for sponges; to design, implement and finely tune models of development for reproductive organs in flowering plants and for sponges; to develop a customisable modelling and simulation platform adapted to the study of complex systems in the context of development biology.» weiterlesen» einklappen