Kurzfassung

Oxidative stress results in the dysregulation of glucose metabolism. The resulting Warburg metabolism might be an early effect in cancer. Therefore the metabolism status is being analyzed in healthy oral mucosal membranes compared to metabolically stressed mucosa (patients at risk and with co-morbidities) and to cancerous mucosal membranes. Markers are ATP, glucose, pyruvat, lactat and the expression level of the cellular membrane transporter for glucose (GLUT1/3) and lactat (MCT1/4). This is...Oxidative stress results in the dysregulation of glucose metabolism. The resulting Warburg metabolism might be an early effect in cancer. Therefore the metabolism status is being analyzed in healthy oral mucosal membranes compared to metabolically stressed mucosa (patients at risk and with co-morbidities) and to cancerous mucosal membranes. Markers are ATP, glucose, pyruvat, lactat and the expression level of the cellular membrane transporter for glucose (GLUT1/3) and lactat (MCT1/4). This is correlated with the clinical outcome of the patients.» weiterlesen» einklappen