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Oxytocin changes behavior and spatio-temporal brain dynamics underlying inter-group conflict in humans

EUROPEAN NEUROPSYCHOPHARMACOLOGY. Bd. 31. 2020 S. 119 - 130

Erscheinungsjahr: 2020

ISBN/ISSN: 0924-977X

Publikationstyp: Zeitschriftenaufsatz

Doi/URN: 10.1016/j.euroneuro.2019.12.109

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Inhaltszusammenfassung


Inter-group conflicts drive human discrimination, mass migration, and violence, but their psychobiological mechanisms remain largely unknown. Here, we investigated whether the neuropeptide oxytocin modulates behavior and spatio-temporal brain dynamics in naturalistic inter-group conflict. Eighty-six male members of natural rival social groups received either oxytocin or placebo intranasally. In a decision-making paradigm involving real monetary stakes, participants could sacrifice their own r...Inter-group conflicts drive human discrimination, mass migration, and violence, but their psychobiological mechanisms remain largely unknown. Here, we investigated whether the neuropeptide oxytocin modulates behavior and spatio-temporal brain dynamics in naturalistic inter-group conflict. Eighty-six male members of natural rival social groups received either oxytocin or placebo intranasally. In a decision-making paradigm involving real monetary stakes, participants could sacrifice their own resources to modulate the monetary gains and losses of in- and out-group members. Oxytocin eliminated the reduction in out-group gains - particularly in individuals with low emotional empathy, whereas those given placebo exhibited this negative social behavior. Our spatio-temporal analysis of event-related potentials elicited by outcome valuation revealed that oxytocin replaced a neurophysiological process associated with the negative valuation of out-group gains via a process associated with positive valuation between 200-500ms after outcome presentation. Oxytocin thus seems to modulate inter-group behavior in humans via a specific alteration of valuation-related brain dynamics. (C) 2019 Published by Elsevier B.V. » weiterlesen» einklappen

Autoren


Schiller, Bastian (Autor)
Heinrichs, Markus (Autor)

Verknüpfte Personen


Gregor Domes

Beteiligte Einrichtungen