Häm-Interaktionen an der Schnittstelle zwischen SARS-CoV-2 und Wirtszelle
BIOspektrum. Bd. 29. H. 6. Heidelberg: Springer Spektrum 2023 S. 625 - 628
Erscheinungsjahr: 2023
ISBN/ISSN: 1868-6249
Publikationstyp: Zeitschriftenaufsatz
Sprache: Deutsch
Doi/URN: 10.1007/s12268-023-2025-5
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Inhaltszusammenfassung
A link between COVID-19 and heme-driven pathophysiology was recognized early due to SARS-CoV-2-induced autoimmune reactions leading to hemolysis. The accumulating heme has been shown to trigger inflammation and thrombosis. Moreover, heme-binding motifs were identified in the viral spike glycoprotein and protein 7a as well as in the host protein ACE2. Biophysical and in silico studies confirmed heme binding to these proteins, emphasizing the potential relevance of hemolysis in COVID-19.
Klassifikation
DDC Sachgruppe:
Naturwissenschaften
