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Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system

Immunity. Bd. 43. H. 1. New York, NY: Cell Press 2015 S. 92 - 106

Erscheinungsjahr: 2015

ISBN/ISSN: 1097-4180 ; 1074-7613

Publikationstyp: Zeitschriftenaufsatz

Sprache: Englisch

Doi/URN: 10.1016/j.immuni.2015.06.012

Volltext über DOI/URN

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Inhaltszusammenfassung


During early embryogenesis, microglia arise from yolk sac progenitors that populate the developing central nervous system (CNS), but how the tissue-resident macrophages are maintained throughout the organism’s lifespan still remains unclear. Here, we describe a system that allows specific, conditional ablation of microglia in adult mice. We found that the microglial compartment was reconstituted within 1 week of depletion. Microglia repopulation relied on CNS-resident cells, independent from ...During early embryogenesis, microglia arise from yolk sac progenitors that populate the developing central nervous system (CNS), but how the tissue-resident macrophages are maintained throughout the organism’s lifespan still remains unclear. Here, we describe a system that allows specific, conditional ablation of microglia in adult mice. We found that the microglial compartment was reconstituted within 1 week of depletion. Microglia repopulation relied on CNS-resident cells, independent from bone-marrow-derived precursors. During repopulation, microglia formed clusters of highly proliferative cells that migrated apart once steady state was achieved. Proliferating microglia expressed high amounts of the interleukin-1 receptor (IL-1R), and treatment with an IL-1R antagonist during the repopulation phase impaired microglia proliferation. Hence, microglia have the potential for efficient self-renewal without the contribution of peripheral myeloid cells, and IL-1R signaling participates in this restorative proliferation process.» weiterlesen» einklappen

Autoren


Bruttger, Julia (Autor)
Karram, Khalad (Autor)
Wörtge, Simone (Autor)
Regen, Tommy (Autor)
Marini, Federico (Autor)
Hoppmann, Nicola (Autor)
Klein, Matthias (Autor)
Blank, Thomas (Autor)
Yona, Simon (Autor)
Wolf, Yochai (Autor)
Mack, Matthias (Autor)
Pinteaux, Emmanuel (Autor)
Müller, Werner (Autor)
Zipp, Frauke (Autor)
Binder, Harald (Autor)
Bopp, Tobias (Autor)
Prinz, Marco (Autor)
Jung, Steffen (Autor)
Waisman, Ari (Autor)

Klassifikation


DDC Sachgruppe:
Medizin