Starten Sie Ihre Suche...


Durch die Nutzung unserer Webseite erklären Sie sich damit einverstanden, dass wir Cookies verwenden. Weitere Informationen

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Science. Bd. 350. H. 6263. Washington, DC: American Association for the Advancement of Science 2015 S. 981 - 985

Erscheinungsjahr: 2015

ISBN/ISSN: 1095-9203 ; 0036-8075

Publikationstyp: Zeitschriftenaufsatz

Sprache: Englisch

Doi/URN: 10.1126/science.aac9593

Volltext über DOI/URN

GeprüftBibliothek

Inhaltszusammenfassung


Innate lymphoid cells (ILCs) are a subset of immune cells that promote barrier immunity in tissues such as the gut and lungs and help to maintain immune homeostasis. Gasteiger et al. investigated how the body maintains its pools of ILCs in such peripheral tissues, as well as in immune tissues such as the lymph nodes and the spleen. In mice surgically joined to share their bloodstreams, unlike lymphocytes, most ILCs did not circulate through the blood. Instead, ILCs resided long term in tissue...Innate lymphoid cells (ILCs) are a subset of immune cells that promote barrier immunity in tissues such as the gut and lungs and help to maintain immune homeostasis. Gasteiger et al. investigated how the body maintains its pools of ILCs in such peripheral tissues, as well as in immune tissues such as the lymph nodes and the spleen. In mice surgically joined to share their bloodstreams, unlike lymphocytes, most ILCs did not circulate through the blood. Instead, ILCs resided long term in tissues, even in the face of inflammation or infection.Science, this issue p. 981Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear. We found that in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were maintained and expanded locally under physiologic conditions, upon systemic perturbation of immune homeostasis and during acute helminth infection. However, at later time points after infection, cells from hematogenous sources helped to partially replenish the pool of resident ILCs. Thus, ILCs are maintained by self-renewal in broadly different microenvironments and physiological settings. Such an extreme “sedentary” lifestyle is consistent with the proposed roles of ILCs as sentinels and local keepers of tissue function.» weiterlesen» einklappen

Autoren


Gasteiger, Georg (Autor)
Fan, Xiying (Autor)
Dikiy, Stanislav (Autor)
Lee, Sue Y. (Autor)
Rudensky, Alexander Y. (Autor)

Klassifikation


DDC Sachgruppe:
Medizin