Phenotypic characterisation of pro-inflammatory monocytes and dendritic cells in peripheral arterial disease
Thrombosis and haemostasis. Bd. 108. H. 6. Stuttgart: Schattauer 2012 S. 1009 - 1248
Erscheinungsjahr: 2012
ISBN/ISSN: 0340-6245
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1160/TH12-05-0327
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Inhaltszusammenfassung
Atherosclerosis is a chronic inflammatory process involving antigen-presenting cells like monocytes and dendritic cells (DC). The aim of this study was to perform a phenotypic characterisation of these cell types in patients with different degrees of peripheral arterial disease (PAD). Sixty patients with PAD [N= 30 intermittent claudication (IC), N= 30 critical limb ischemia (CLI)] and 30 controls were included. Peripheral blood leucocytes were analysed from peripheral blood by flow cytometry...Atherosclerosis is a chronic inflammatory process involving antigen-presenting cells like monocytes and dendritic cells (DC). The aim of this study was to perform a phenotypic characterisation of these cell types in patients with different degrees of peripheral arterial disease (PAD). Sixty patients with PAD [N= 30 intermittent claudication (IC), N= 30 critical limb ischemia (CLI)] and 30 controls were included. Peripheral blood leucocytes were analysed from peripheral blood by flow cytometry using different gating strategies to directly identify and analyse monocytes, myeloid DC, (mDC) and plasmacytoid DC (pDC). PAD patients showed a significantly higher proportion of proinflammatory CD14++CD16+ monocytes (p» weiterlesen» einklappen
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Medizin
