Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
Nature nanotechnology. Bd. 8. H. 10. London: Nature Publishing Group 2013 S. 772 - 781
Erscheinungsjahr: 2013
ISBN/ISSN: 1748-3395 ; 1748-3387
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1038/nnano.2013.181
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Inhaltszusammenfassung
In biological fluids, proteins bind to the surface of nanoparticles to form a coating known as the protein corona, which can critically affect the interaction of the nanoparticles with living systems. As physiological systems are highly dynamic, it is important to obtain a time-resolved knowledge of protein-corona formation, development and biological relevancy. Here we show that label-free snapshot proteomics can be used to obtain quantitative time-resolved profiles of human plasma coronas f...In biological fluids, proteins bind to the surface of nanoparticles to form a coating known as the protein corona, which can critically affect the interaction of the nanoparticles with living systems. As physiological systems are highly dynamic, it is important to obtain a time-resolved knowledge of protein-corona formation, development and biological relevancy. Here we show that label-free snapshot proteomics can be used to obtain quantitative time-resolved profiles of human plasma coronas formed on silica and polystyrene nanoparticles of various» weiterlesen» einklappen
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Medizin
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