Kurzfassung

We have elucidated in the past in vitro potential procoagulant signal transduction pathways in the antiphospholipid syndrome. In the current project we want to validate whether these signal transduction pathways are relevant in the in vivo situation. To this end two mouse models will be used: (1) an in vivo stasis model in which flow in the vena cava is massively slowed down, and (2) a carotid artery model based on mechanical injury to the vessel wall. Animal will be injected with monoclonal...We have elucidated in the past in vitro potential procoagulant signal transduction pathways in the antiphospholipid syndrome. In the current project we want to validate whether these signal transduction pathways are relevant in the in vivo situation. To this end two mouse models will be used: (1) an in vivo stasis model in which flow in the vena cava is massively slowed down, and (2) a carotid artery model based on mechanical injury to the vessel wall. Animal will be injected with monoclonal antiphospholipid antibodies and thrombus formation will be quantified. The use of genetically modified mice will permit the validation of the involved signal transduction pathways.» weiterlesen» einklappen