Kurzfassung

Muscle injuries are very common in athletes. So far there is no consensus on their management. Recently, several new injection methods were reported to shorten the recovery time after structural muscle injuries. In this context the application of Actovegin and Traumeel (Tr14) as commonly used by Dr. Müller-Wohlfahrt is the most controversial and widely discussed. Only limited scientific evidence can be found in the literature to generally support the use of these agents to treat structural...Muscle injuries are very common in athletes. So far there is no consensus on their management. Recently, several new injection methods were reported to shorten the recovery time after structural muscle injuries. In this context the application of Actovegin and Traumeel® (Tr14) as commonly used by Dr. Müller-Wohlfahrt is the most controversial and widely discussed. Only limited scientific evidence can be found in the literature to generally support the use of these agents to treat structural muscle injuries. In our controlled in vitro study we investigate the biological impact of Actovegin and Tr14 alone and in combination on primary human skeletal muscle cells. We could demonstrate that Actovegin and Tr14 have modulatory effects on primary human skeletal muscle cells in vitro. Low volumes of actovegin stimulate in tendency cell proliferation and significantly up-regulate gene expression of myosin, NCAM and Pax7 after 7 days of culture. Higher volumes of actovegin significantly inhibit cell viability and significantly down-regulates Pax7 gene expression. Tr14 in tendency reveals to have an inhibiting effect on cell viability and gene expression of myosin reaching significance for Pax7 and NCAM gene expression with higher volumes. The combination of both agents in culture did not significantly influence cell proliferation, although there was a significant down-regulation of NCAM and Pax7 gene expression with higher volumes. The relevance of these in vitro findings in terms of the muscle healing process has to be clarified in further in vivo studies.» weiterlesen» einklappen