Kurzfassung

Elevated levels of adult neurogenesis have been proposed as a resilience-conducive trait that protects against stress-related dysfunction by facilitating discrimination during and/or after stressor exposure, the latter being supposed to represent an active resiience mechanism. In A02, we aim at revealing the dependence of resilience to stress-related dysfunction on the degree of circuit integration of adult-born dentate granule cells (DGCs) as determined by rabies virus-based tracing of...Elevated levels of adult neurogenesis have been proposed as a resilience-conducive trait that protects against stress-related dysfunction by facilitating discrimination during and/or after stressor exposure, the latter being supposed to represent an active resiience mechanism. In A02, we aim at revealing the dependence of resilience to stress-related dysfunction on the degree of circuit integration of adult-born dentate granule cells (DGCs) as determined by rabies virus-based tracing of monosynaptic input connections. We will correlate circuit integration of DGCs and resilience to chronic social defeat stress and search for activity- and neuro-trophin-induced manipulations that improve resilience outcome as a consequence of altered connectivity.» weiterlesen» einklappen