Kurzfassung

The physicochemical stability ready-to use preparations of different antitumor medicinal products, e.g. carfilzomib, decitabine und plerixafor ist studied. Physical stability test encompass particle counts, pH, osmolality and colour. Chemical stability test focus on different HPLC methods (RP-HPLC, SEC-HPLC) and electrophoresis. Thereby qualitative and quantitative parameters are determined. With regard to the microbiological stability the viability of four different pathogens (S....The physicochemical stability ready-to use preparations of different antitumor medicinal products, e.g. carfilzomib, decitabine und plerixafor ist studied. Physical stability test encompass particle counts, pH, osmolality and colour. Chemical stability test focus on different HPLC methods (RP-HPLC, SEC-HPLC) and electrophoresis. Thereby qualitative and quantitative parameters are determined. With regard to the microbiological stability the viability of four different pathogens (S. aureus, E. coli, P. aeruginosa, C. albicans) related to hospital infections to grow in ready-to-use, cytotoxic and non-cytotoxic parenteral products aseptically prepared in hospital pharmacies is measured. Compatibility of anticancer drug-loaded DC Beads™ (bead size 70-150 µm, 100-300 µm) with different types and volumes of commonly nonionic contrast media used by the interventional radiologists (as  Accupaque™ 300 (Iohexol), Imeron® 300 (Iomeprol), Ultravist® 300 (Iopromid), Visipaque™ 320 (Iodixanol)) is investigated.» weiterlesen» einklappen