Kurzfassung

Teilprojekte SFB 1066 B03 + B04 + B05 +B06 + B08 + B11 + Q2
The coordinated research center CRC 1066 aims at the development of functional nano-particular carriers as basis for a tumor-immuno therapy of the malignant melanoma (as a model tumor). For this purpose chemists, biologists and medical scientists work together in three highly interrelated research lines: (1) By synthesizing a broad variety of nano-particular carrier systems, which can be adjusted to the special needs of the...Teilprojekte SFB 1066 B03 + B04 + B05 +B06 + B08 + B11 + Q2
The coordinated research center CRC 1066 aims at the development of functional nano-particular carriers as basis for a tumor-immuno therapy of the malignant melanoma (as a model tumor). For this purpose chemists, biologists and medical scientists work together in three highly interrelated research lines: (1) By synthesizing a broad variety of nano-particular carrier systems, which can be adjusted to the special needs of the immunotherapy, we lay the foundation for a localized modulation of the immune-system. (2) By characterizing the interaction of these particles with biological media and cells, we learn how to control cell-uptake and biodistribution and how to vary them to address the immune-system most effectively. (3) By performing functional in vitro and in vivo experiments, we study the effect of these carriers on subsets of the immune-cell population and on the immune system as a whole, aiming at a response directed against the melanoma, as our model system.
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