Kurzfassung

Posttranscriptional mechanisms controlling gene expression play an increasingly recognized role in health and disease. While substantial progress has been made to characterize many of these mechanisms, the regulation of mRNA 3’end processing is still poorly understood. Importantly, alternative and regulated mRNA 3’end processing modulates the expression of many genes - often in response to extracellular stimuli. Despite these findings, the involved signal-transduction pathways and their role...Posttranscriptional mechanisms controlling gene expression play an increasingly recognized role in health and disease. While substantial progress has been made to characterize many of these mechanisms, the regulation of mRNA 3’end processing is still poorly understood. Importantly, alternative and regulated mRNA 3’end processing modulates the expression of many genes - often in response to extracellular stimuli. Despite these findings, the involved signal-transduction pathways and their role to execute specific cellular programs are unknown.
We will integrate bioinformatical, biochemical and functional genomic approaches to dissect the molecular and cellular mechanisms of regulated mRNA 3’end processing. We aim to identify functionally relevant factors and signaling pathways that modulate this step of mRNA maturation in response to environmental cues. These findings will be translated into disease models that could ultimately provide novel insights into in vivo-validated targets and/or signaling
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