Kurzfassung

The present challenge is to understand the prevalence and incidence of T790M, other EGFR mutations or already known signaling pathway mutations and whether they contribute to a drug-resistant phenotype in advanced gastroesophageal cancers.
Thus, the evaluation of the prognostic and predictive values of these mutations in terms of overall (OS) and progression free survival (PFS) is warranted.
In this context, an immunohistochemical evaluation of PD-L1 of the indicated material will be evaluated...The present challenge is to understand the prevalence and incidence of T790M, other EGFR mutations or already known signaling pathway mutations and whether they contribute to a drug-resistant phenotype in advanced gastroesophageal cancers.
Thus, the evaluation of the prognostic and predictive values of these mutations in terms of overall (OS) and progression free survival (PFS) is warranted.
In this context, an immunohistochemical evaluation of PD-L1 of the indicated material will be evaluated and later correlated with NGS results. Further objectives of this project are to test the correlations of the gene mutations mentioned above and of the PDL-1 expression with clinical-pathological parameters such as gender, age, exact tumour localization, positivity for an infection with helicobacter pylori.
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