Kurzfassung

Crohn's disease and ulcerative colitis are the two most important chronic inflammatory states of the gastrointestinal tract. These chronic inflammatory diseases occur frequently in young and adolescent patients. Interestingly, they typically lead to premature occurrence of age-associated diseases, such as intestinal atrophy or colorectal tumor formation. Except for a few exceptions, age-associated mechanisms are largely unexplored in these disease entities. We are interested in whether...Crohn's disease and ulcerative colitis are the two most important chronic inflammatory states of the gastrointestinal tract. These chronic inflammatory diseases occur frequently in young and adolescent patients. Interestingly, they typically lead to premature occurrence of age-associated diseases, such as intestinal atrophy or colorectal tumor formation. Except for a few exceptions, age-associated mechanisms are largely unexplored in these disease entities. We are interested in whether various changes known to occur during aging also happen prematurely in chronic inflammatory diseases and weather this has any clinical implications in the development and severity of inflammatory bowel diseases.  The focus is on specific immune cell subpopulations and their interaction with the intestinal epithelial cells (immunosenescence and immunoaging). Here, too, we are using different preclinical models and different clinical cohorts of patients with Crohn's disease and ulcerative colitis.» weiterlesen» einklappen