Kurzfassung

Colorectal carcinoma (CRC) is the second most common cancer world-wide and is characterized by a high mortality due to metastasis. The mechanisms determining the development of metastasis are still far from clear. A thorough understanding of the complex processes underlying metastatic progression would therefore provide a basis for major advancements in the diagnosis and treatment of CRC.
Our previous work revealed that the expression of the multifunctional phosphoprotein PEA-15 is associated...Colorectal carcinoma (CRC) is the second most common cancer world-wide and is characterized by a high mortality due to metastasis. The mechanisms determining the development of metastasis are still far from clear. A thorough understanding of the complex processes underlying metastatic progression would therefore provide a basis for major advancements in the diagnosis and treatment of CRC.
Our previous work revealed that the expression of the multifunctional phosphoprotein PEA-15 is associated with tumor-specific survival of CRC patients, invasion depth, and presence of lymph node metastasis. We identified PEA-15 as a central regulator of cell death resistance and invasiveness.
Based on these data, we aim at delineating the regulation of invasiveness and metastasis by PEA-15 in CRC at the cellular and molecular level. Further, the expression of PEA-15 and its phosphorylated forms will be analyzed in primary versus metastatic tumor tissue.» weiterlesen» einklappen