Kurzfassung

The hypothesis is that the biochemical composition and particle size of bone substitute materials play a pivotal role in their degradation and vascularization and, thus, in the rate and quality of new bone formation. This study will focus on the vascularization as well as ostoegenesis of BoneCeramic (Straumann) a biphasic calciumphosphate ceramic (HA/ß-TCP) in vitro and in vivo. This study analyzes the effect of BoneCeramics biochemical composition and particle size on human endothelial cells...The hypothesis is that the biochemical composition and particle size of bone substitute materials play a pivotal role in their degradation and vascularization and, thus, in the rate and quality of new bone formation. This study will focus on the vascularization as well as ostoegenesis of BoneCeramic® (Straumann) a biphasic calciumphosphate ceramic (HA/ß-TCP) in vitro and in vivo. This study analyzes the effect of BoneCeramic´s biochemical composition and particle size on human endothelial cells and osteoblasts in vitro. In vivo, its interaction (osteoconduction vs. osteoinduction) is evaluated in an animal model. Non-commercially obtained hydroxyapatite (HA) and ß-tricalciumphospate (ß-TCP) granules serve as controls. Combined in vitro and in vivo studies should enable a better understanding of the cell and tissue reaction to BoneCeramic®.» weiterlesen» einklappen