Kurzfassung

Causes of lower back pain are multifactorial, but in the majority of cases it is linked to clinical evidence of IVD degeneration. As a consequence, curing disc degeneration is one of the most important socioeconomic imperatives facing modern health care. 30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed research work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair...Causes of lower back pain are multifactorial, but in the majority of cases it is linked to clinical evidence of IVD degeneration. As a consequence, curing disc degeneration is one of the most important socioeconomic imperatives facing modern health care. 30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed research work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell- loaded bioactive polymer-based scaffolds will be developed. These will be designed to be implanted into the patient by minimally invasive surgery. A biomimetic approach will confer the appropriate mechanical and biological properties and enable the inclusion of the requisite cell signalling factors to produce a bio-hybrid structure which closely resembles the human tissue in all its essential attributes. Particular attention will be paid to angiogenesis. In IVD tissue, vascularization must be carefully controlled, due to the unique anatomy and physiology of the intervertebral disc. There must be negligible vascularization in the annulus and nucleus regions and moderate vascularisation at the vertebral body level. Work will therefore be performed on materials functionalization, and on growth factor incorporation and delivery, to enable this region-specific control of vascularisation at different levels. Natural IVD tissue contains a relatively low number of cells, which are chondrocyte- like in character. Consequently, it will be necessary to devo te some research to identifying and evaluating suitable and more readily available alternative cells for incorporation in the bio-hybrid substitutes produced. Modelling studies will identify the physical and mechanical properties of the natural IVD and the substitute materials, and provide an understanding of the physical aspects of the regeneration process. In vivo study on animal model will be performed the bio -functionality of both substitutes. Surgical methodology and protocol will be developed to provide data for commercially- implementable, added value technologies.» weiterlesen» einklappen