Kurzfassung

The NanoBioPharmaceutics (Nanoscale Functionalities for Targeted Delivery of Biopharmaceutics) project is positioned as a R & D initiative in the NMP (Nanotechnologies, Materials, Production) research priority of the Sixth EU Framework Programme for Research and Technological Development. This project aims at the development of novel biopharmaceutics attached to nanocarriers for targeted delivery for medical applications. A major issue is the development of suitable biopharmaceutics...The NanoBioPharmaceutics (Nanoscale Functionalities for Targeted Delivery of Biopharmaceutics) project is positioned as a R & D initiative in the NMP (Nanotechnologies, Materials, Production) research priority of the Sixth EU Framework Programme for Research and Technological Development. This project aims at the development of novel biopharmaceutics attached to nanocarriers for targeted delivery for medical applications. A major issue is the development of suitable biopharmaceutics nanocarrierer systems for the treatment of neurodegenerative diseases, cancer and diabetes as an example. Nanocarrier-based protein/peptide delivery systems will be developed for pulmonary, oral and blood brain barrier (BBB) crossing applications. These developments can have a huge impact on improving the quality of life of citizens in and outside Europe. The objectives of the NanoBioPharmaceutics project are: Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based microcarriers for targeted delivery of P/P(protein/peptide) drugs via oral, pulmonary and blood brain barrier (BBB) crossing administration routes. Toxicological screening of the nanocarriers and investigation of the release profile of P/P drug under various environmental conditions and the assessment of the biocompatibility and biodegradability of the new formulations. Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung. Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties. Development of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB). » weiterlesen» einklappen