Kurzfassung

Molecular mechanisms involved in inherent and aquired drug resistance of tumor cells have been studied for many years. With respect to the anticancer drug cisplatin decreased intracellular accumulation, increased detoxification and more efficient repair of DNA damage have been identified as mechanisms of resistance. Furthermore, inhibition of programmed cell death is well known to contribute to tumor cell resistance. Recently, new mechanisms of drug resistance have been discovered involving...Molecular mechanisms involved in inherent and aquired drug resistance of tumor cells have been studied for many years. With respect to the anticancer drug cisplatin decreased intracellular accumulation, increased detoxification and more efficient repair of DNA damage have been identified as mechanisms of resistance. Furthermore, inhibition of programmed cell death is well known to contribute to tumor cell resistance. Recently, new mechanisms of drug resistance have been discovered involving cell-extracellular matrix and cell-cell interactions, therefore termed cell adhesion-mediated drug resistance and multicellular resistance, respectively. In cell adhesion-mediated drug resistance, protective signaling pathways, induced by activation of cell-extracellular matrix adhesion molecules such as integrins, decrease the sensitivity of different cell types to cytotoxic agents, among others to cisplatin. The aim of this project is to characterize the signaling pathways that are responsible for aquired cisplatin resistance of laryngeal carcinoma cells. In particular, the functional relevance of Rho-regulated signaling mechanisms for cell adhesion-mediated cisplatin resistance is going to be elucidated.» weiterlesen» einklappen